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현재위치 : HOME > 자료실 |
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작성일
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2006-03-30 15:19:10 |
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비타민 A는 여러 관련 물질을 통칭하는 일반명이다. 레티놀(retinol, 알코올 an alcohol)과 레티날(retinal, 알데하이드 an aldehyde)은 대개 미리 형성된(preformed) 비타민 A로 불린다. 레티날은 몸에서 레티노산(retinoic acid, RA) 즉 유전자 전사(gene transcription)에 관여하는 형태의 비타민 A로 전환될 수 있다. 레티놀, 레티날, 레티노산과 관련 화합물들을 레티노이드(retinoids)라고 한다. 베타-카로틴(β -carotene)과 몸 속에서 레티놀로 전환될 수 있는 다른 카로티노이드들을 풋비타민 A 카로티노이드(provitamin A carotenoids)라 한다. 식물은 수백 가지의 서로 다른 카로티노이드를 합성하지만 이 중 약 10% 만이 풋비타민 A 카로티노이드에 해당된다.
기능 Function
시각 Vision
레티놀은 혈액 순환에 의해 망막으로 운반되어 망막의 색소 상피세포 속으로 들어가 로돕신으로 변화하여 막대세포(rod cell)로 들어가며 이 로돕신을 함유한 막대세포는 아주 적은 양의 빛도 포착할 수 있으므로, 어두운 곳에서의 시력에 중요하다. 레티놀이 망막으로 충분히 공급되지 않으면 어두운 곳에서 적응하기 어려우며 이를 “야맹(night blindness)”이라 한다.
세포분화 관련기능
비타민 A의 두 번째 주된기능은 세포분화 즉 ‘전단계 세포를 특정 기능을 가진 세포로 발달시키는 과정’에서 나타난다. 이외에도 비타민 A는 정자형성, 면역반응, 미각, 청각, 식욕 및 성장등의 생리적 과정에 필수적인 것으로 알려져 있다.
면역 Immunity
비타민 A는 흔히 감염에 대항하는 비타민으로 알려져 있는데, 이는 면역체계의 정상적인 기능을 위해 필요하기 때문이다. 피부와 점막 세포(기도, 소화관, 요로)는 장벽으로 기능하여 몸의 첫 번째 방어막을 형성한다. 비타민 A와 레티노산(RA)은 림프구(lymphocyte) 등 백혈구의 성장과 분화에 중심적인 작용을 하는데 이들은 면역 반응에 결정적인 역할을 한다.
성장과 발달 Growth and Development
비타민 A의 과잉과 부족은 둘 다 출생 결손(birth defect)을 일으키는 것으로 알려져 있다. 레티놀과 레티노산은 배아(embryo)의 발달에 필수 불가결하다. 태아의 발달 과정에서, 레티노산은 사지(limb)의 발달과 심장, 눈, 귀의 형성에 필요하다. 또한, 레티노산은 성장 호르몬에 의한 유전자의 발현을 조절하는 것으로 밝혀졌다.
적혈구 생산 Red Blood Cell Production
적혈구는 다른 모든 혈액 세포와 마찬가지로 줄기세포(stem cell)라 불리는 세포에서 분화되어 나온다. 이러한 줄기세포는 적혈구로의 정상적인 분화를 위해서 레티노이드에 의존한다.
영양소 상호작용 Nutrient Interactions
아연과 비타민 A (Zinc and Vitamin A).
아연이 결핍되면 순환을 통해 레티놀을 망막 등의 조직으로 운반하는데 필요한 레티놀 결합 단백질(retinol binding protein, RBP)의 합성이 감소되고 간에서 레티놀의 저장 형태인 레티닐 팔미테이트(retinyl palmitate)로부터 레티놀을 분비시키는 효소의 활동성을 저해한다.
철분과 비타민 A (Iron and Vitamin A).
비타민 A 결핍은 철 결핍성 빈혈을 악화시킬 수 있다. 비타민 A 보충제는 철 결핍성 빈혈 환자에게 도움을 주고 소아와 임산부의 철분 상태를 호전시키는 것으로 알려져 왔다.
결핍증 Deficiency
비타민 A 결핍과 시력 Vitamin A Deficiency and Vision
개발도상국의 소아에서 비타민 A 결핍은 실명(blindness)의 예방 가능한 원인의 주요 부분을 차지한다. 비타민 A 결핍의 가장 초기에 나타나는 증상은 어두운 곳에서 적응하는 능력이 떨어지거나 야맹증(night blindness)이 나타나는 것이다.
영양 권장량 The Recommended Dietary Allowance
우리나라의 권장량에 의하면 일반 성인 남녀와 임신부의 경우 임신전반기에는 하루 700RE, 임신 후반기에는 800RE, 그리고 수유부의 경우1,000RE를 섭취하도록 권장하고 있다.
질병 예방 Disease Prevention
암 Cancer
세포 배양(cell culture) 연구와 동물 실험에 의하면 천연/합성 레티노이드는 피부, 유방, 간, 대장, 전립샘 등의 암 형성(carcinogenesis)을 감소시키는 능력이 있다.
공급원 Sources
식품 공급원 Food Sources
자유 레티놀(free retinol)은 일반적으로 식품 속에서는 발견되지 않는다. 레티놀의 전구물질이며 저장 형태인 레티닐 팔미테이트(retinyl palmitate)는 일반적으로 동물성 식품에 함유되어 있다. 식물성 식품은 카로티노이드(carotenoids)를 함유하고 있으며, 이 중 일부 즉 알파-카로틴과 베타-카로틴 등은 비타민 A의 전구물질이다. 카로티노이드는 노란색 야채와 오렌지에 많이 들어있다. 녹색 야채도 카로티노이드를 함유하고 있으나, 카로티노이드의 노란색 색소는 녹색 색소인 엽록소(chlorophyll)에 가려져 있다. 비타민 A가 풍부한 식품공급원에는 동물의 간이나 어유, 달걀, 당근, 토마토, 살구 등이다.
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